7-1．簡単な解説

脳卒中は世界の死因の2位を占め、年間600万人超が死亡している(WHO,2015)。脳卒中の大半を占める脳梗塞に有効な線溶系を活性化する物質を菌類などから検索した結果、プラクチン,スタプラビンとSMTP同族体（SMTP-1-6）、クロノスタチン,新規脂肪酸など10余の新規化合物を発見し、構造決定と作用を研究した。本テーマの共同研究者・蓮見恵司氏（東京農工大学）はその後SMTP同族体の研究を更に進め、脳梗塞治療薬の開発を目指して、臨床試験フェーズ２に進んでいる（原著論文１-12）。

7-2. 原著論文(12編)

1. 1) Inoue T, Hasumi K, Kuniyasu T, Endo, A. Isolation of plactins A, B, C and D, novel cyclic pentapeptides that stimulate cellular fibrinolytic activity. J Antibiot 1996; 49: 45-49.
2. 2) Shinohara C, Hasumi K, Hatsumi W, Endo A. Staplabin, a novel fungal　triprenyl phenol which stimulates the binding of plasminogen to fibrin and U9937 cells. J Antibiot 1996; 49: 961-966.
3. 3) Tachikawa K, Hasumi K, Endo A. Enhancemennt of plasminogen binding to U937 cells and fibrin by complestatin. Thromb Haemostat 1997; 77: 137-142.
4. 4) Chikanishi T, Hasumi K, Harada T, Kawasaki N, Endo, A. Clonostachin, a nove peptaibol that inhibits platelet aggregation. J Antibiot 1997; 50: 105-110."
5. 5) Kohyama T, Hasumi K, Hamanaka A, Endo A. SMTP-1 and 2, novel analogs of staplabin produced by Stachybotrys microspora IFO 30018. J Antibiot 1997; 50: 172-174.
6. 6) Tachikawa K, Hasumi K, Endo A. Enhancement of plasminogen binding and fibrinolysis by chloropeptin. Thromb Res 1997; 87: 571-576.
7. 7) Takayasu R, Hasumi K, Shinohara C, Endo A. Enhancement of fibrin-binding and activation of plasminogen by staplabin thorugh an induction of a conformational change in plasminogen. FEBS Lett 1997; 418: 58-62.
8. 8) Inoue T, Hasumi K, Sugimoto M, Endo A. Enhancement of fibrinolysis by plactins: structure-activity relationship and effects in human U937 cells and in mice. Thromb Haemostat 1998; 79: 591-596.
9. 9) Hasumi K, Ohyama S, Kohyama T, Ohsaki Y, Takayasu R, Endo. A Isolation of SMTP-3,-4,-5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis. J Antibiot 1998; 51:1059-1068.
10. 10) Shinohara C, Hasumi K, Chikanishi T, Kikuchi T, Endo A. 11-Keto9(E),
11. 12) (E)-octadecadienoic acid, a novel fatty acid that enhances fibrinolytic activity of endothelial cells. J Antibiot 1999; 52: 171-174.
12. 11) Chikanishi T, Shinohara C, Kikuchi T, Endo A, Hasumi K. Inhibition of plasminogen activator inhibitor-1 by 11-keto-9(E), 12(E)-octadecadienoc acid, a novel fatty acid produced by Trichodema sp. J Antibiot 1999; 52: 797-802.
13. 12) Shinohara C, Chikanishi T, Nakashima S, Hashimoto A, Hamanaka A,Endo A, Hasumi K. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetogloboisn A, crinipellin B, geodin and triticone B. J Antibiot 2000; 53: 262-268.